SHEN Chaohui, LUO Yonglan,ZHANG Meiling, ZHONG Bingbing, CHEN Guangqing, ZHOU Suxian

( Departmen of Endocrinology, Affiliated Hospital of Guilin Medical 

University, Guilin 541001, China)

Abstract Objective The correlation between serum cystatin C ( Cys-C) , β2-microglobulin ( β2-MG) , uric acid ( UA ) and diabetic nephropathy ( DN ) was analyzed, and the correlative factors for better diagnosis of diabetic nephropathy ( DN) were deduced. Methods 259 diabetic patients were selected to collect the related indexes of Cys-C, β2-MG and UA, and the relationship between the related indexes and urinary albumin/creatinine ratio (UACR) was analyzed using the corresponding statistics. Results UACR≥ 30 mg/g, as the diagnostic threshold of DN, showed that 6 indicators, including Cys-c, β2-MG, UA, systolic blood pressure ( SBP) , 2-hour postprandial blood glucose ( 2 h PG) and disease duration, were independent risk factors for UACR. When a diabetic patient has Cys-c ≥ 1. 435 mg/L, β2-MG ≥ 2.055 mg/L,UA≥ 320 μmol/L, SBP ≥ 145 mmHg, 2 h PG ≥ 8.5 mmol/L, and duration of illness ≥ 4.5 years, the patient has a higher risk of developing early DN with a corresponding threshold probability of prevalence of 81.5%. Conclusion Combined testing of the six indicators of Cys-c, β2-MG, UA, SBP, 2 h PG and disease duration can better predict the development of DN.

Keywords: diabetic nephropathy; urinary albumin/creatinine ratio; serum cystatin C; β2-microglobulin; uric acid; systolic blood pressure; 2 h postprandial blood glucose

DOI:10.19296/j.cnki.1008-2409.2024-03-019

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